Director, New Product Commercialization

Alnylam is expanding its Pipeline Commercialization capability to match the ambition and complexity of one of the most productive development pipelines in the company's history. The Director, New Pipeline Commercialization will be a member of the Value & Pipeline Commercialization (VPC) team, serving as a key commercial contributor across multiple development-stage assets with a primary focus on Alnylam's late stage pipeline assets such as Zilebesiran and ALN-6400.

This individual will report to the VP, Zilebesiran Commercialization Lead and will operate as a hands-on strategic contributor - owning defined commercial workstreams, leading external engagements with customers and alliance partners, and supporting the commercial development of multiple pipeline assets simultaneously. The ideal candidate thrives at the intersection of science and strategy, brings deep new product planning experience, and is energized by the opportunity to shape development decisions years before launch.

Key Responsibilities

Commercial Strategy & Asset Support

• Serve as a pivotal member of the commercial team for Alnylam's Zilebesiran & ALN-6400 programs, leading defined workstreams within the go-to-market framework, stage-gate roadmap, and positioning
• Develop commercial strategy for additional pipeline assets across the VPC portfolio - driving market assessments, target product profile development, patient population analysis, and early commercialization plans
• Develop and maintain a well-supported commercial point of view on each assigned asset, including competitive positioning hypotheses, unmet need framing, and launch assumptions
• Build the analytical foundation and commercial narrative that enables senior leadership to make high-quality decisions in governance and development board forums
• Contribute to forecast assumption development and financial modeling for assigned assets

Integrated Evidence & Market Insights

• Lead defined workstreams within the Integrated Evidence Plan, developing the commercial rationale for specific evidence generation initiatives - articulating what each study enables commercially and how it connects to positioning and differentiation at launch
• Partner with Medical Affairs to ensure commercial perspective is reflected in evidence generation planning, publications strategy, and scientific communications
• Design and execute, in collaboration with Market research team, primary market research programs, translating business questions into clear research objectives and converting findings into strategic recommendations
• Synthesize competitive intelligence, secondary data, and treatment landscape dynamics into actionable insights that inform both asset-level and portfolio-level decisions

VPC Team & Organizational Capability

• Play an active role in building the VPC team's ways of working - contributing to frameworks, tools, and processes that improve how the team operates across multiple assets simultaneously
• Support the development of commercial best practices for pipeline-stage assets, including approaches to evidence planning, stage-gate design, and cross-functional influence in development organizations

External Engagement

• In partnership with medical, lead external engagement with KOLs, clinical experts, and advisory boards - independently representing Alnylam's commercial perspective in scientific and strategic settings, and translating expert input into commercial insight
• Support alliance partner workstreams by preparing commercial materials, analyses, and strategic inputs that enable productive joint planning and evidence generation discussions
• Engage with patient communities and advocacy organizations to ensure the patient perspective is embedded in commercial and evidence planning

Qualifications

• Bachelor's degree required; MBA or advanced degree strongly preferred
• 8+ years of experience in pharmaceutical/biotech/healthcare consulting industry with experiences in new product planning, pipeline commercialization, launch strategy, and/or brand strategy
• Demonstrated ability to lead commercial workstreams independently and represent the commercial perspective credibly with external scientific and clinical experts
• Experience in or exposure to alliance or co-development environments preferred
• Strong command of market research design, competitive intelligence synthesis, and evidence-to-strategy translation
• Proven ability to influence cross-functional teams without direct authority, including medical, clinical, regulatory, and access partners
• Strong analytical skills including the ability to develop and pressure-test forecast assumptions
• Clear and compelling communicator - able to synthesize complex information into concise commercial narratives and prepare senior leaders for high-stakes forums
• Comfortable operating on a long development horizon - able to think ambitiously, set early hypotheses, and adapt as evidence evolves

U.S. Pay Range

$208,300.00 - $281,800.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.