Researcher 6

Summary:
NIH- funded position to study the effects of mutations in the assembly of the PKA-R subunit complexes. The overarching goal of the project is to determine the effects of these mutation in the progression of rare diseases such as Cushing's syndrome and fibrolamellar hepathocellular carcinoma.

Duties as Researcher 6 will principally include the protein expression and purification, design, implementation, and interpretation of experiments aimed at investigating the structural dynamics of soluble and membrane proteins using a variety of NMR techniques. The Researcher 6 will be responsible for writing all manuscripts communicating experimental results. The Researcher 6 will also assist in the technical training and supervision of technicians, undergraduate, and graduate students, and in planning/drafting relevant portions of extramural grants to continue support of the project. Finally, the Researcher 6 participates actively in relevant seminars, journal clubs and symposia.

Essential Functions:
65% Experimental design and implementation - protein expression and purification, design, implementation, and interpretation of experiments aimed at investigating the structural dynamics of soluble and membrane proteins using a variety of NMR techniques.

20% Training/supervision of technicians and undergraduates - Teach technical staff newly developed methodologies and supervise data acquisition.

5% Participation in seminars, journal clubs and symposia - Will present at least 1 formal seminar per year (locally or at relevant national meeting) and regularly attend relevant local seminars and journal clubs.

5% Assist in planning and drafting extramural research proposals - Will work with direct supervisor to plan and draft portions of research grants relevant to newly developed methodologies.

5% Drafting scientific manuscripts - Will serve as primary author of manuscripts communicating experimental results.

Required Qualifications:
Ph.D. in Chemistry, Biochemistry, Molecular Biology with substantial research and publication record.

Preferred Qualifications:
4 years of experience with solution or solid-state NMR spectroscopy, having a strong theoretical background in pulse sequences for solution-state and experience in assignment and determination of protein structure.

BMBB:
The department of Biochemistry, Molecular Biology and Biophysics is committed to understanding the molecular mechanisms of metabolic diseases and cancer; developing novel strategies in biocatalysis and biotechnology; and advancing knowledge through structural biology and molecular biophysics. We organize ourselves into research divisions with emphases on Chemical and Structural Biology, Metabolic and Systems Biology, Molecular Biology and Synthetic Biology and Biotechnology. We are housed in new buildings with state-of-the-art research and support facilities.

Working at the University

At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work.

The University also offers a comprehensive benefits package that includes:

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training and degree-seeking programs supported by the Regents Tuition Benefit Program
• Low-cost medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Disability and employer-paid life insurance
• Employee wellbeing program
• Excellent retirement plans with employer contribution
• Public Service Loan Forgiveness (PSLF) opportunity
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost
• Employee Transit Pass with free or reduced rates in the Twin Cities metro area

Please visit the Office of Human Resources website for more information regarding benefits.

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.

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The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.

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