Bioinformatics Scientist II Associate

Position Title: Bioinformatics Scientist - II (Associate)

Work Location: Cambridge, MA 02141

Assignment Duration: 23 months

Work Schedule: M-F 8-5

Work Arrangement: Onsite

Position Summary: The Precision Genetics group seeks a data scientist for multi-modal, multi-scale data analyses to support innovative research efforts.

Background & Context:

• Department: Data and Genome Sciences
• Group: Precision Genetics
• The Precision Genetics group within the Data and Genome Sciences Department is seeking a skilled Contractor to join our Computational Precision Immunology team.
  
  Key Responsibilities:
• Data Ingestion: Query external databases to acquire relevant multi-omics datasets (e.g., PubMed, Gene Expression Omnibus, ArrayExpress, gnomAD, GTEx, Ensembl).
• RNA-seq Analysis: Perform quality control (QC) and analysis of bulk and single-cell RNA-seq data using state-of-the-art methods (e.g., FastQC, STAR, Limma, DESeq2, clusterProfiler, Seurat, scanpy, LeafCutter).
• Multi-Omics Analysis: Analyze diverse molecular data types including spatial transcriptomics (e.g., Slide-seq, MERFISH, squidpy) and proteomics (e.g., OLINK, mass spectrometry-based approaches).
• Data Integration: Integrate multi-omics datasets, including gene/protein expression, mRNA splicing, spatial transcriptomics, and genotype data.
• Documentation: Prepare detailed documentation of analysis methods and results in a timely manner.
  
  Qualification & Experience:
• Ph.D. in Computational Biology or a related field.
• A proven track record of over 3 years in multi-omics analysis.
• Fundamental understanding of statistical methods and multi-omics data analysis and integration (e.g., RNA-Seq, single-cell RNA-Seq, genotype, spatial transcriptomics, OLINK).
• Proficiency in R, Python, and Bash, with the ability to establish best practices for reproducible data analyses.
• Experience with high-performance computing (HPC) systems and AWS Cloud Computing (e.g., IAM, S3 buckets).
• A collaborative and self-motivated individual with a strong work ethic, capable of managing multiple objectives in a dynamic environment and adapting to changing priorities.
• Excellent written and verbal communication skills.
• Preferred: Experience in processing and analyzing real-world data.
• Preferred: Familiarity with spatial transcriptomics analysis.
• Preferred: Knowledge of statistical and population genetics principles.