New

Research Scientist II - Methods Development Lab

Broad Institute
United States, Massachusetts, Cambridge
Jun 23, 2025
Description & Requirements The combination of molecular and computational advances over the past decade has substantially augmented our ability to create transformative methods. While this accelerated pace of methods development offers great promise, the rapid expansion of novel techniques gives rise to new challenges in effective adoption and implementation. To capitalize on these exciting advances, the Broad Institute has formed the Methods Development Lab (MDL), with the mission of identifying key scientific frontiers, generating high-performance end-to-end methods, and driving cutting-edge applications with collaborators across the research community. Research Scientist II: We are seeking a Research Scientist II to drive the development and enable scaled application of single-cell sequencing technologies. A core research aim at the MDL is to catalyze a transformational shift in single-cell sequencing capabilities, making 1 million cell experiments routine and 1 billion cell flagship projects possible. In addition to scale, we have a strong research emphasis on creating advanced library construction techniques that increase capture efficiency and enable multimodal measurements. Much of this work is enabled by bringing industry partners together, achieving new capabilities through shared ambitious goals. The Research Scientist II will drive key projects in this space, executing on project plans, communicating progress, and fostering strong and productive partnerships with industry collaborators. In addition to methods development, The Research Scientist II will drive application of these novel methods at the Broad Institute and work closely with Broad Clinical Lab's production teams to translate novel methods into production scale processes to make them available to the community. * PLEASE INCLUDE A COVER LETTER WITH YOUR APPLICATION * RESPONSIBILITIES: Design and drive technology development projects. Work closely with computational biologists to create analytic methods for novel technologies and resources for the community. Work closely with Broad Clinical Labs to enable single-cell method productionization. Collaborate with Broad Labs to enable single-cell applications. Set and communicate goals, priorities, timelines, and budgets for projects. Track and report progress in an organized fashion. Evaluate new -omic technologies to determine utility, impact, fit with Broad Clinical Labs capabilities and interests. Keep current with the state of the field and interests/needs of Broad researchers. Assists and actively participates in obtaining federal, philanthropic, institutional, or industrial funding opportunities. Publish novel methods. Present work both internally and externally. Seek intellectual property protection for inventions that are conceived of or developed while a member of the MDL. Provide strategic guidance to the MDL Group Leader SKILLS AND ABILITIES: Strong individual contributor with the ability to quickly pivot and collaborate with key stakeholders and senior leadership. Must be forward-thinking and innovative, with a nimble scientific/technical mind, able to rapidly develop and execute on creative solutions. Extensive molecular biology experience. Extensive experience with single-cell technologies. Extensive experience developing methods. Must be skilled at supervising or interacting with teams of researchers, providing both scientific mentorship and direction. Must be proficient in setting goals, priorities, and budgets to drive efficient project execution. Strong data analysis skills. QUALIFICATIONS: PhD in Molecular Biology or related field with 4+ years of experience.