Molecular Biology / Functional Genomics Senior Research Scientist

Job Description

Vertex Pharmaceuticals Inc. is seeking a highly motivated and experienced Senior Scientist to join our Molecular and Cell Biology Department in San Diego. The successful candidate will play a crucial role in advancing our understanding of human genetic diseases and applying this knowledge to support innovative drug discovery and disease modeling efforts. The successful candidate will utilize advanced molecular biology technologies, genomics and bioinformatics approaches to inform drug discovery strategies, guide the generation of predictive disease models and evaluate therapeutic candidates.

Responsibilities:

• Design and execute complex molecular biology experiments to investigate mechanisms of genetic diseases.
• Develop and implement state-of-the art molecular biology and functional genomics approaches, including CRISPR screening techniques, high-throughput QPCR, scRNA-seq and spatial transcriptomics to understand causal disease biology and identify and validate drug targets.
• Generate, analyze and interpret gene expression data using appropriate statistical and bioinformatics tools.
• Collaborate with cross-functional teams including Computational Genomics, Cell Biology and Pharmacology to advance research goals and drug development programs.
• Present research findings at internal meetings to team members, collaborators and senior leadership.

Education and Experience:

• Ph.D. (or equivalent degree) in molecular biology, cell biology, biochemistry, or related disciplines and 2-5 years of relevant post-doctoral employment experience, or
• Masters Degree (or equivalent degree) in molecular biology, cell biology, biochemistry, or related disciplines and 5+ years of relevant employment experience, or
• Bachelors Degree (or equivalent degree) in molecular biology, cell biology, biochemistry, or related disciplines and 8+ years of relevant employment experience
• Extensive knowledge and hands on experience in state-of-the-art molecular biology techniques, including molecular cloning, PCR, sequencing technologies including Illumina NGS, Oxford Nanopore long read sequencing and others.
• Proficiency and hands on experience in CRISPR genome editing and functional genomics approaches.
• Experience with image-based as well as sequence-based spatial transcriptomics technologies.
• Strong background in human genetics and disease biology.
• Experience with bioinformatic tools and data analysis.
• Excellent communication and presentation skills.
• Innovative thinking and problem-solving aptitude.
• Ability to work independently and as part of a collaborative team.
• Efficient multi-tasking skills

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Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com