Sr. Research Investigator, Structural Biology

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

We are seeking a highly motivated and experienced crystallographer to join our structural biology team within the Protein Science and Technology department. The successful candidate will help accelerate gene-to-structure workflows and will play a pivotal role integrating Protein Engineering, Crystallography and AI to support small molecule and biologics drug discovery. The position requires great wet lab skills, and a team-oriented approach to characterize protein samples and/or complexes and deliver high-quality co-crystal structures. In addition, the candidate will be involved in the management of a state-of-the-art Crystallography laboratory and external collaborations to support a diverse portfolio of projects.

• Crystallography experience is required. Cryo-EM experience is desirable, but not required.
• Requires good skills on recombinant protein purification, crystallization and structure determination.
• Help troubleshooting recombinant protein expression and purification.
• Protein engineering experience is highly desirable.
• Train, mentor, and supervise a team of scientists, technicians, and support staff.
• Membrane protein experience is highly desirable but not required.
• Knowledge of protein structure prediction and computational approaches for protein design is desirable.
• Stay current on emerging technologies and instrumentation in protein chemistry, biochemistry and structural biology to introduce innovative approaches.
• Troubleshoot and optimize workflows to improve the efficiency and reproducibility of experimental results.

Key Responsibilities:

• Responsible for gene-to-structure experiments. Crystallization, data collection, structure determination and reporting structures.
• Protein Expression: Design and manage strategies for expression of targets.
• Protein Purification: Design, optimize, and execute protocols for the purification of recombinant proteins using various chromatography techniques (e.g., affinity, ion exchange, size exclusion).
• Biophysical Characterization: Perform biophysical characterization of purified proteins samples and complexes including but not limited to analytical SEC, DSF, TSA.
• Data Analysis & Reporting: Maintain detailed records of experimental designs, data, and results. Analyze and interpret data for presentation to key stakeholders.

Qualifications (Minimal acceptable level of education, work experience, and competence)

* Ph.D. in chemistry, structural biology, biochemistry or related field with a minimum of 5 years of experience in biotech or large pharmaceutical company, or BS/MS with 10 years with equivalent experience.

* Post-doctoral and/or industrial experience supporting drug discovery programs using structural biology is desirable.

* Good communication and interpersonal skills.

* Proven experience working with matrix teams and leadership skills are highly desirable.

* Self-driven, creative and entrepreneurial with ability to support multiple programs simultaneously.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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