Project Scientist-Biological Chemistry

Job requirements

This position is intended for collaborative research working on X chromosome dosage compensation mechanisms in mouse and humans and the role of X-linked gene expression in the placenta. The Plath lab uses cutting-edge stem cell biology, mouse models, gene regulation, imaging, and omics techniques to study these questions.

The preferred qualifications for this position are as follows:

• Ph.D. in Gene Regulation, Biochemistry, Cell Biology, Developmental Biology, Stem Cell Biology, or a related field.
• At least 3 years of postdoctoral experience with a strong publication and collaborative record.
• Expertise in X-chromosome dosage compensation.
• Proficiency in molecular biology techniques, including RNA-seq, ATAC-seq, CRISPR-Cas9 genome editing, and advanced imaging.
• Experience in bioinformatics and analyzing single cell and bulk genomics dat.
• Strong organizational, problem-solving, and communication skills.
• Demonstrated ability to lead independent projects and work collaboratively within a team.

Job duties and responsibilities

1. Design and conduct experiments to dissect molecular mechanisms underlying gene expression dosage compensation on the X chromosomes in placental mammals and apply genetic approaches to test functional relationships.
2. Lead and execute projects focused on the understanding the role of X-linked genes expression in the placenta, at the feto-maternal interphase.
3. Use state-of-the-art omics including genomics, metabolomics, proteomics and imaging techniques to characterize cell populations and lineage specification and their X-linked gene expression in vivo and in vitro.
4. Utilize mouse models and human tissues in addressing questions of interest.
5. Perform the analyses and interpretation of resulting genomics data.
6. Develop and optimize protocols for the analysis of the mouse placenta by single cell and single nucleus genomics approaches.
7. Collaborate with other lab members and external collaborators to integrate multi-disciplinary approaches into the studies of X-chromosome dosage compensation.
8. Mentor junior scientists, postdocs, and students in experimental design, data analysis, and scientific writing.
9. Contribute to the preparation of research manuscripts for publication, grant proposals, and progress reports and gather pilot data for grant proposals.
10. Responsible for the maintenance of lab instruments and training new users in their operation. Help with safety protocols.
11. Seek funds to establish own independence.

Ph.D. in Biological Chemistry or related fields

• 2-4 required (contact information only)

Please provide contact information for 2 references.

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct, are currently being investigated for misconduct, left a position during an investigation for alleged misconduct, or have filed an appeal with a previous employer.

• "Misconduct" means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, discrimination, dishonesty, or unethical conduct, as defined by the employer.
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