New

Research Technician II Formulation

Mass General Brigham (Enterprise Services)
United States, Massachusetts, Cambridge
65 Landsdowne Street (Show on map)
Apr 18, 2025
GENERAL SUMMARY / OVERVIEW: The Gene and Cell Therapy Institute (GCTI) is a newly created system-wide Institute under Mass General Brigham. The Institute will foster a world-class gene and cell therapy program that will leverage ongoing, groundbreaking scientific research efforts across the MGB system. The mission of GCTI is to bring together the community of MGB investigators which can utilize gene and cell therapy platforms to achieve their scientific and clinical goals and improve the health of patients. The Institute will differentiate itself by harnessing the exceptional strengths of clinician scientists, the large and unique patient population, and major discoveries throughout the hospital system to propel MGB as the leader in Gene & Cell therapies. We are seeking a motivated and skilled Technician to join our RNA Therapeutics Core (RTC) team and participate in the development of novel RNA-based medicines and technologies. With guidance from senior scientific staff, the candidate who fills this role will produce and analyze high quality lipid nanoparticle formulations of RNA for experimental applications and external parties, and administer formulated RNA to mice via different injection routes. The successful candidate will have experience working in a research laboratory environment and be proficient in standard mouse handling techniques such as tail vein injections, subcutaneous injections, and sample collection, as well as lipid nanoparticle formulation. They would preferably have hands-on LNP process development experience, be detail-oriented and organized, and eager to work in a team environment. Bachelor's degree in life sciences, biochemistry, chemistry, or chemical engineering with at least 1-2 years of experience in a laboratory setting Good organizational skills, detail oriented Reproducibility of work with accuracy Sound degree of computer literacy Ability to methodically record data Good interpersonal and communication skills Ability to demonstrate professionalism Dedication to excellence PREFERRED COMPETENCIES: Experience working with mice Experience formulating and analyzing lipid nanoparticles PRINCIPAL DUTIES AND RESPONSIBILITIES: Perform a variety of routine procedures following established methodologies including lipid nanoparticle formulation, flash freezing, and dialysis Perform analytical techniques such as dynamic light scattering and concentration measurements via nucleic acid entrapment assay and record quality metrics, with a strong focus on accuracy and reproducibility in work Perform routine mouse handling procedures including tail vein injection, anesthetization, tail and cheek bleeds, live imaging, and wellness monitoring Operate laboratory equipment, instruments and robotics to perform repetitive laboratory techniques; learn how to use new instruments Use universal safety precautionsand proper personal protective equipment to protect self and co-workers from biohazardous materials; complete requisite trainings as appropriate Participate in lab meetings and generate ideas for improving efficiency and productivity in the lab's operations Communicate effectively with the team, discuss progress, and share data with supervisors All other duties as assigned Mass General Brigham Incorporated is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.