Job Description Summary:
The Associate Scientist II, Neuroscience is responsible for performing scientific experiments that contribute to research and drug discovery activities at PTC. This position assists in the conduct of early stage research, the goal of which is the identification of New Chemical Entities (NCEs), as well as the advancement of research programs from the identification of screening hits to advanced lead optimization. The incumbent is also responsible for communicating experimental results to his/her supervisor and the project team.
The Associate Scientist II, Neuroscience supports adherence to all regulatory requirements and company Standard Operating Procedures (SOPs) including as appropriate.
Job Description:
Key Responsibilities Under minimal supervision, executes experiments as directed by the supervisor and communicates results as part of multi-disciplinary team(s). May also design and conduct independent research experiments.
- Analyze data from experience and understanding of databases such as prism, excel, etc.
- Applies relevant scientific principles and techniques to research problems.
- Maintains detailed laboratory notebooks.
- Maintains broad knowledge of state-of-the-art principles and techniques and may contribute to the identification of new project areas or technologies.
- Presents findings internally and externally and contributes to the publication of the work of the project team in well-established and peer reviewed journals, subject to internal scientific and legal approval.
- May provide technical and scientific input to the project team or research leadership
- Contributes to the development of patent applications as appropriate.
- Complies with all safety requirements.
- Contributes to general lab operations such as:
- Equipment maintenance.
- Identification of capital equipment needs
- Maintenance of clean and uncluttered work areas
- Maintain Inventory and order supplies as needed.
- Provides support for high throughput screening including the design of primary assays, the goal of which is the identification of additional hits and new chemical scaffolds.
- Provides support for lead optimization by screening compounds and/or supporting structure activity relationship (SAR) studies involving the characterization of the biological activity of compounds in various assays. Profiles selected compounds in additional cells/assays.
- Executes weekly cell-based screening assays to support hit to lead optimization efforts for early-stage discovery programs.
- Conducts mechanism of drug activity studies.
- Routinely uploads and reports data in a timely fashion which may also include communicating any delays or changes in workflow to a cross disciplinary team.
KNOWLEDGE/SKILLS/ABILITIES REQUIRED Describe the following criteria, which are necessary to effectively perform the position:
- Experience developing cell-based assays
- Ability to design and execute experiments
- Excellent sterile technique and extensive cell culture experience
- Immunoassay experience (ELISA, MSD) - moderate to high-throughput assays for protein detection using different platforms
- Experience in RNA purification, qPCR and analysis
- Perform cell culture duties including media and reagent preparation, media exchange/feeding, counting, passaging, imaging, and characterization
- Background in Neuroscience/Cell biology and Molecular biology
Qualifications * Minimum level of education and years of relevant work experience.
- Bachelor's degree in a scientific discipline, preferably Biology or Neuroscience with a minimum of 6 years' experience or Master's degree in a scientific discipline and a minimum of 2 years relevant experience. Please note, this is not a PhD position.
* Special knowledge or skills needed and/or licenses or certificates required.
- Demonstrates high technical proficiency, scientific creativity, independent thought, and the ability to collaborate with others on cross functional teams in a fast-paced, matrixed, environment consisting of internal and external team members.
- Possesses knowledge of scientific principles and concepts and keeps current with relevant scientific literature.
- Proficiency with Microsoft Office- preferably MS Excel and MS PowerPoint.
- Effective verbal and written communication and skills.
- Analytical thinker with problem-solving skills and the ability to adapt to changing priorities and deadlines.
- Effective planning, organization and time management skills including the ability to support and prioritize multiple projects.
- Experience independently designing assays, troubleshooting assay parameters, and analyzing data are critical for this position.
* Travel requirements Up to 5% *Physical requirements (only note if the job requires physical capacity beyond general office work) Office/Laboratory based position Expected Base Salary Range: $101,200 -$119,000 The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position. In addition, to the base salary, PTC employees are also eligible for short - and long-term incentive. All eligible employees may enroll in PTC medical, dental, vision and retirement savings plans, EEO Statement: PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination. Click here to return to the careers page
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PTC Therapeutics, Inc
Mar 12, 2025