New 
Scientist
 Spectraforce Technologies | |
 United States, Massachusetts, Worcester | |
 Feb 20, 2025 | |
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Job Title: Scientist
Location: Worcester, MA Duration: 12 months Description: Contractor (Scientist II) - Biologics Developability Screening and Automation The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development organization. The Biologics CMC Developability team conducts high-throughput screening of physicochemical properties of discovery-stage biologic drug candidates to identify liabilities, helping in the selection of lead candidates for pipeline advancement. We have an exciting opportunity for a motivated scientist to join the Client's Biologics CMC Developability team based in Worcester, MA. Key Responsibilities: * Conduct laboratory-based high-throughput screening and analytical, biophysical, and biochemical characterization of biologic drug candidates. Perform experiments to screen physicochemical properties of biologic molecules (antibodies, bispecific antibodies, antibody drug conjugates, and genetic medicine modalities) and identify liabilities that may impact drug development. * Enable automation and high-throughput screening of discovery candidate molecules. * Execute experimental protocols, collect results, and perform data analysis independently. * Maintain excellent documentation of work including electronic lab notebook and protocols. * Prepare and deliver concise scientific presentations of experimental results. * Oversee maintenance of key laboratory equipment and routine laboratory operations. * Build strong relationships with other team members and across groups. * Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance. Qualifications: * BS or MS in Biochemistry, Biology, Chemistry (or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences) with 3+ (BS) or 1+ years (MS), biopharmaceutical industry experience preferred. * Hands-on experience in protein biochemical and biophysical characterization. Experience with diverse biologic formats desired. * Detailed knowledge of protein structure, biophysical characterization, and formulation screening. * Experience in protein biophysical and biochemical characterization techniques, including chromatography (size-exclusion, ion exchange and hydrophobic interaction chromatography), differential scanning calorimetry & fluorimetry, dynamic light scattering, UV-VIS and fluorescence spectroscopy, imaged capillary isoelectric focusing, capillary electrophoresis, particle and viscosity measurements. Must be willing and able to learn new technologies as needed. * Prior experience in high-throughput automation and mass spectrometry would be beneficial. * Demonstrated track record of independent thinking, creativity, and scientific accomplishment. * Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables. Able to perform data analysis using MS Excel & GraphPad. * Team player with excellent collaboration and communication skills. | |